ZANILEX 4

Product Category: Muscle relaxants

Composition: Tizanidine Hydrochloride 4mg tablet

Therapeutic Category: Centrally acting α2-adrenergic receptor agonist

Mechanism of Action: Tizanidine hydrochloride acts as a centrally acting α2-adrenergic receptor agonist. Its primary mechanism involves reducing muscle spasticity by inhibiting the release of excitatory amino acids like glutamate and aspartate from spinal interneurons. This action leads to presynaptic inhibition of motor neurons, which results in muscle relaxation and reduced spasms.

Indications:

 Chronic Neck and Lower Back Pain: It may be used to manage chronic pain in these areas.

 Rebound Headaches: Tizanidine can be used for headaches resulting from analgesic withdrawal.

 Chronic Migraine Headaches: It is sometimes prescribed for managing migraine headaches.

 Refractory Insomnia: In some cases, it is used to treat insomnia, particularly in patients with spastic quadriplegia.

 Regional Musculoskeletal Pain Syndromes: Tizanidine may be used for managing pain in these conditions.

Dosage:

 Initial Dose: Start with 2 mg orally every 6 to 8 hours as needed.

 Dose Titration: Gradually increase the dose by 2 to 4 mg at intervals of 1 to 4 days until satisfactory reduction of muscle tone is achieved.

 Maximum Dose:

 Single Dose: Do not exceed 16 mg.

 Daily Dose: Do not exceed 36 mg in a 24-hour period.

 Administration Frequency: Up to three doses per day, spaced 6 to 8 hours apart.

Pack Size: Available in 10 Strips