CLOBEST CREAM

Product Category: Anti-fungal agents

Composition: Clotrimazole (1%)

Therapeutic Category: Anti-fungal

Mechanism of Action: Clotrimazole 1% cream works by disrupting fungal cell membranes through ergosterol inhibition. It blocks the enzyme lanosterol 14α-demethylase, preventing ergosterol synthesis, which weakens the membrane and causes leakage of essential components, leading to fungal cell death. It is effective against Candida, dermatophytes (Trichophyton, Microsporum), and Malassezia furfur, making it useful for skin and vaginal fungal infections.

Indications:

Used for conditions like Dermatophytoses (Skin Infections), Candidiasis (Yeast Infections), Pityriasis (Tinea) Versicolor, Otomycosis, Onychomycosis (Nail Fungal Infection)

Dosage:

A. For Adults and Children (Above 12 Years)

 Skin infections (ringworm, athlete’s foot, jock itch, etc.)

Apply twice daily (morning and night) to the affected area.

Continue for 2–4 weeks, depending on the infection.

Wash and dry the area before application.

 Vaginal yeast infections:

Apply inside the vagina once daily at bedtime for 7 days (for 1% cream).

B. For Children (Ages 2–12 Years)

 Skin infections:

Apply a thin layer twice daily for 2–4 weeks.

If symptoms do not improve in 2 weeks, consult a doctor.

 Diaper rash or fungal infections in infants:

Apply a very thin layer twice daily for 7–14 days.

Only use under a doctor’s supervision.

C. For Infants (Below 2 Years)

Use only if prescribed by a doctor.

For diaper rash, antifungal creams like Clotrimazole may be used, but pediatric guidance is necessary.

Pack Size: Available in 15gm Tube