Product Category:

Drugs for Neuropathy

Composition:

Pregabalin Capsules IP (75mg)

Therapeutic Category:

Gabapentinoid

Mechanism of Action:

The definite mechanism of action of Pregabalin has not been described. However, there is evidence that this drug acts by binding to α2δ subunit of voltage-dependent calcium channels, preventing influx of calcium ion in the pre-synaptic neuron. It prevents membrane depolarization and release of excitatory neurotransmitters to the synapse hence reducing neuronal firing and demonstrating its efficacy in epilepsy, GAD and neuropathic pain.

Indications:

For the management of neuropathic pain (Diabetic neuropathy, Peripheral neuropathy, post-herpetic neuralgia, trigeminal neuralgia), fibromyalgia, as an adjunctive therapy in adults with partial seizures with or without secondary generalization, generalized anxiety disorder

Dosage:

The dose range for pregabalin is 150 to 600 mg per day given in either two or three divided doses. • For neuropathic pain and partial seizure, pregabalin can be started at a dose of 150 mg per day given as two or three divided doses. Based on the response and tolerability, the dose may be increased to 300 mg per day after an interval of 3 to 7 days, and if needed, to a maximum dose of 600 mg per day after an additional 7-day interval. • For generalized anxiety disorder, the dose range is 150 to 600 mg per day given as two or three divided doses. The need for treatment should be reassessed regularly.

Pack Size:

10*10s (Strips)