METROPAN DF

Metronidazole 400mg and Diloxanide Furoate 500mg

Product Category: Antibiotic and Antiprotozoal Agent

Composition: Metronidazole 400mg and Diloxanide Furoate 500mg

Therapeutic Category: Antibiotic and Antiprotozoal Agent

Mechanism of Action: Metronidazole works by entering the cells of anaerobic bacteria and protozoa. Once inside the cell, it is reduced by the electron transport proteins, resulting in the formation of toxic metabolites. These metabolites bind to the DNA of the microorganism, causing DNA strand breakage and inhibiting DNA synthesis, leading to cell death. This action is particularly effective against anaerobic bacteria and protozoa, as they rely on anaerobic metabolism, which activates the drug.

Indications:

The combination of Metronidazole 400mg and Diloxanide Furoate 500mg is specifically indicated for the treatment of intestinal amoebiasis caused by Entamoeba histolytica, including:

 Symptomatic amoebiasis: Treating the active trophozoite form of the parasite (with Metronidazole).

 Asymptomatic amoebiasis or cyst carriers: Preventing recurrence of the infection by targeting the cyst form (with Diloxanide Furoate).For the treatment of amoebiasis:

Adults: One tablet of Metropan DF taken three times a day for 10 days.

Dosage:

For the treatment of amoebiasis:

Adults: One tablet of Metropan DF taken three times a day for 10 days.

Pack Size: Available in 30 Strips